Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

نویسندگان

  • Lili Cheng
  • Huiling Tan
  • Xiaoyu Wu
  • Ruijun Hu
  • Carlin Aw
  • Min Zhao
  • Han-Ming Shen
  • Yixin Lu
چکیده

Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-alpha-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-alpha-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 6 22  شماره 

صفحات  -

تاریخ انتشار 2008